Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
نویسندگان
چکیده
منابع مشابه
Cancer Therapy: Preclinical Preclinical Antitumor Activity of Cabazitaxel, a Semisynthetic Taxane Active in Taxane-Resistant Tumors
Purpose: Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane developed to overcome taxane resistance. Experimental Design:Cabazitaxel effects on purified tubulin and on taxane-sensitive or chemotherapyresistant tumor...
متن کاملPreclinical antitumor activity of cabazitaxel, a semisynthetic taxane active in taxane-resistant tumors.
PURPOSE Taxanes are important chemotherapeutic agents with proven efficacy in human cancers, but their use is limited by resistance development. We report here the preclinical characteristics of cabazitaxel (XRP6258), a semisynthetic taxane developed to overcome taxane resistance. EXPERIMENTAL DESIGN Cabazitaxel effects on purified tubulin and on taxane-sensitive or chemotherapy-resistant tum...
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Microtubule stabilizing drugs such as taxanes have proven fairly effective for treating solid tumors, but the mechanism by which these drugs treat cancer is still unsolved. Intratumor imaging, showing that the cell proliferation rate is low in many chemosensitive human cancers, has challenged the dogma that the cytotoxicity of such compounds is the result of their effect on rapidly dividing cel...
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BMS-275183 is a taxane, the mechanism of action of which is like other known taxanes, and is the polymerization of tubulin. BMS-275183 given p.o. was as effective as i.v. paclitaxel in five tumor models [murine M109 lung and C3H mammary 16/C, and human A2780 ovarian (grown in mice and rats) and HCT/pk colon]. It was active in one other tumor model (human HCT-116 colon) but inferior to parentera...
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IDN5109 is a new taxane, derived from 14beta-hydroxy-10-deacetylbaccatin III, selected for its lack of cross-resistance in tumor cell lines expressing the multidrug resistant phenotype. Because, unlike paclitaxel, IDN5109 is a poor substrate for P-glycoprotein, we hypothesized that IDN5109 given p.o. could improve bioavailability compared with paclitaxel. Here, we studied the p.o. and i.v. phar...
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ژورنال
عنوان ژورنال: Clinical Cancer Research
سال: 2013
ISSN: 1078-0432,1557-3265
DOI: 10.1158/1078-0432.ccr-12-3146